Kushen, a traditional Chinese medicine, has the functions of clearing away heat and dampness, reducing inflammation and detoxifying, and its alkaloids are its main anti-tumor substances. In recent years, as the extract of Kushen, compound Kushen injection has the characteristics of significant anti-tumor efficacy and few side effects, it is often combined with various anti-tumor treatments such as surgery, chemotherapy, radiotherapy, and targeted therapy in clinical practice in China. This paper summarizes the animal and clinical experiments of cervical, breast, gastric, and colon cancer through the drug effect of the compound Kushen injection. Many studies have shown that compound Kushen injection mainly exerts its anti-tumor effect by regulating tumor cell proliferation, inducing tumor cell apoptosis, reducing tumor angiogenesis, and improving body immunity. Based on traditional anti-tumor therapy, adding the compound Kushen injection can have a more apparent therapeutic effect on patients, reduce the side effects of anti-tumor therapy, improve patients' quality of life, and prolong patients' survival time. This paper significantly summarizes the research on the anti-tumor treatment of compound Kushen injection, further clarifies the anti-tumor effect of the effective extracts of traditional Chinese medicine, which provides a basis for future anti-tumor research of compound Kushen injection and a basis for the clinical promotion of the drug.

Compound Kushen Injection, Anti-cancer, Traditional Chinese Medicine, Clinical Application

Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jiang(2023). CLINICAL RESEARCH PROGRESS OF COMPOUND KUSHEN INJECTION ON ANTI-TUMOR EFFECT. Journal of Cancer Sciences (Hong Kong), Volume 2, Issue 1, Page 1-16, Publish Date：2023-05-09.